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19-20 Nov 2021

 

Gliwice

 

ASCR

 

NIO

 

PolSL

 

PTP

 

Finprot

 

Gliwickie Spotkania Naukowe 2019” - zadanie finansowane w ramach umowy nr 511/P-DUN/2019 ze środków Ministra Nauki i Szkolnictwa Wyższego przeznaczonych na działalność upowszechniającą naukę

XXV Gliwice Scientific Meetings, 2021

Scientific Program 

[GSM 2021 Conference materials - PDF]

 

Thursday, 18th November 18, 2021, 14:00 – 20:00 CET

Joint online seminar of the Polish Proteomics Society and the Finnish Proteomics Society:

"Proteomics of Extracellular Vesicles"

Registration

The seminar participants should register by November 17, 2021. The request for registration should be sent by e-mail via Polish Proteomics Society <This email address is being protected from spambots. You need JavaScript enabled to view it.> or Finnish Proteomics Society <This email address is being protected from spambots. You need JavaScript enabled to view it.>.

The relevant link to the ZOOM platform meeting will be sent to registered participants only. The seminar has no registration fee.

 

Chairpersons: Tuula Nyman (Oslo) & Piotr Widłak (Gliwice)

14.00 – 16.00 Part 1
Maija Puhka (Finnish Institute of Molecular Medicine, HiLIFE, University of Helsinki, Helsinki): Considerations of factors affecting proteomes in extracellular vesicle isolates: preanalytics and beyond.

Harry Holthöfer (Finnish Institute of Molecular Medicine, University of Helsinki, Helsinki and University Medical Center Hamburg-Eppendorf, Hamburg): Urinary extracellular vesicles: from process optimization to applications.

Marit Inngjerdingen (Institute of Clinical Medicine, Oslo University Hospital, Oslo): Dissection of functionally distinct EV subset released from NK cells guided by proteomics.

Raghu Kalluri (The University of Texas MD Anderson Cancer Center, Houston): The biology and function of exosomes in cancer.

16.00 – 16.15 Break


16.15 – 18.15 Part 2
Mari Palviainen (EV-group, University of Helsinki, Helsinki): Ins and outs of extracellular vesicles.

Susana Garcia-Silva (Microenvironment and Metastasis Group, Spanish National Cancer Research Center – CNIO, Madrid): Extracellular vesicles cargo on melanoma’s service and against it.

Beate Vestad (Research Institute of Internal Medicine, Oslo University Hospital, Oslo): Plasma extracellular vesicles in people living with HIV and type 2 diabetes are related to microbial translocation and cardiovascular risk.

Anna Wojakowska (Institute of Bioorganic Chemistry, Poznań): Small extracellular vesicles represent different proteomic pattern in response to neoadjuvant radiotherapy in rectal cancer patients.

18.15 – 18.30 Break


18.30 – 20:00 Part 3
Mayank Saraswat (Mayo Clinic, Rochester): Extracellular vesicle composition and biology: What can we learn from quantitative proteomics?

Dmitry Ter-Ovanesyan (Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston): Separating EVs from free proteins in biofluids.

Monika Pietrowska (MSC National Research Institute of Oncology, Gliwice): Analysis of exosomeshuttled proteins using immunocapture approaches followed by high resolution mass spectrometry.

 

The seminar organizing committee:
Maciej Lalowski (University of Helsinki, Helsinki, Finland)
Magdalena Łuczak (Institute of Bioorganic Chemistry, Poznań, Poland)
Tuula Nyman (Institute of Clinical Medicine, Oslo University Hospital, Oslo, Norway)
Monika Pietrowska (Maria Skłodowska-Curie National Research Institute of Oncology, Gliwice, Poland)
Theresa Whiteside (Hillman Cancer Center, University of Pittsburgh, Pittsburgh, USA)
Piotr Widlak (Maria Skłodowska-Curie National Research Institute of Oncology, Gliwice, Poland) 

 

 

Friday, 19th November 2021

XXV Gliwice Scientific Meetings, 2021 

9.00 – 9.15                 Opening of the conference and welcome addresses

9.15 – 10.15               Special session:

“Professor Mieczysław Chorąży – 70 years of research in tumor biology”

Rememberance of Prof. Mieczysław Chorąży

            Announcement of the Laureate of the Prof. Mieczysław Chorąży Scholarship

            The Mieczysław Chorąży Lecture 2021 –

Kari Hemminki (Charles University, Pilsen & DKFZ, Heidelberg):  “Science and society”.

10.15 – 10.30             Coffee Break

10.30 – 13.00             Session: “Cancer Moonshot – Early Detection of Lung Cancer

                                   Chairpersons – Piotr Widłak & Witold Rzyman

Witold Rzyman (Medical University of Gdańsk, Gdańsk): Lung cancer screening - where we are?

Luis Montuenga (University of Navarra, Pamplona): The role of molecular markers in the lung cancer screening route [online].

Fabrizio Bianchi (Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo): The small world of microRNAs and their big role in lung cancer [online].

Piotr Widłak (NRIO, Gliwice): Serum metabolome profiling in early detection of lung cancer.

Joanna Polańska (Silesian University of Technology, Gliwice): Radiomics of lung cancer.

Marek Kimmel (Rice University, Houston): Modeling risk of lung cancer: Coordination of molecular events and growth characteristics of tumors.

 

13.00 – 14.00             Lunch Break/poster viewing

14.00 – 18.00             Session: “Chromatin and Regulation of Gene Expression”

Chairpersons – Joanna Rzeszowska & Sergey Razin

Sergey V. Razin (Lomonosov Moscow State University, Moscow): Order and stochasticity in the 3D organization of individual genomes.

Aleksandra Pękowska (Nencki Institute of Experimental Biology, Warszawa): Interplay between chromatin architecture and gene expression.

Michal Gdula (Adam Mickiewicz University, Poznań): How to shut down a whole chromosome? - SmcHD1, epigenetics and 4D genome in X inactivation.

Gracjan Michlewski (International Institute of Molecular and Cell Biology, Warszawa): Regulation of miRNA biogenesis - mechanisms and future therapies.

Agnieszka Ciesielska (10x Genomics, Stockholm): Scale and resolution. Single-cell and spatial transcriptomics - more than marriage from convenience.

16.00 – 16.15         Coffee Break

Martin Simard (Université Laval, Quebec): Regulation and modulation of the microRNA silencing pathway [online].

Victor Ambros (University of Massachusetts Medical School, Worcester): Argonaute mutations that broadly disrupt microRNA activity in worms and human disease [online].

Grant McFadden (Arizona State University, Phoenix): Ex vivo oncolytic virotherapy with myxoma virus [online].

 

19.30 Dinner& Social event (Dworek u Hrabiego, ul. Świętokrzyska 6, 44-100 Gliwice)

 

Saturday, 20th November 2021

9.00 – 10.00               Virtual Poster Session (part 1)/coffee

Short presentations of selected posters (5 minutes allocated to each presentation)

Poster Session 1

  1. Ryszard Smolarczyk Anticancer effect of vascular disrupting agent (CA4P) in combination with STING agonist (cGAMP) in murine breast cancer and melanoma therapy
  2. Marta Gawin Intra-tumor heterogeneity revealed by mass spectrometry imaging is associated with the prognosis of breast cancer
  3. Kinga Pogoda-Mieszczak The usefulness of murine mesenchymal cells as a myxoma virus carrier for the planned therapy of murine glioblastoma
  4. Agnieszka Potęga Glutathione conjugation of the antitumor-active unsymmetrical bisacridine C-2028 in human liver subcellular fractions – the major role of glutathione S-transferase M1-1
  5. Adrianna Rutkowska Analysis of the applicability of antibodies recognizing EGFRvIII in the case of primary glioblastoma cell lines
  6. Mateusz Smolarz Analysis of miRNAs in serum and serum-derived exosomes – putative biomarkers for early detection of cancer in participants of lung cancer screening study
  7. Ali Maruf Trehalose-Releasing Nanogels: A Potential Trehalose Delivery System for Autophagy Stimulation
  8. Joanna Pilch Folic acid-quantum dots platforms for efficient delivery of unsymmetrical bisacridines to lung and prostate cancer cells
  9. Jolanta Kulesza c-Myc protein level affected by unsymmetrical bisacridines plays a role in apoptosis induced by these compounds in HCT116 colorectal and H460 lung cancer cells
  10. Seweryn Gałecki Variants in OPN and CD44 genes may influence recurrence and prognosis in non-small cell lung cancer treated with radiotherapy and chemoradiotherapy
  11. Marcelina Jureczko How fast can be the vincristine removed by white-rot fungi?
  12. Marcela Krzempek COVID-19 vaccinations decrease SARS-CoV-2 incidences: single medical Institute report

10.00 – 11.45             Session: “Radiation Biology and Medicine”

                                   Chairpersons – Dorota Słonina & Nicolas Foray

Nicolas Foray (INSERM, Lyon): The radiation-induced nucleoshuttling of the ATM protein and its medical applications in radiotherapy and radiology.

Carmel Mothersill (McMaster University, Hamilton): New non-targeted mechanisms identified after low dose radiation exposure.

Ludwik Dobrzyński (National Centre for Nuclear Research, Świerk): Yonezawa effect and its modelling.

Marek Janiak (Military Institute of Hygiene & Epidemiology, Warszawa): Antineoplastic effects of low-dose whole-body exposures to X-rays combined with inactivation of two immune checkpoints in mice.

11.45 – 12.00             Coffee Break

12.00 – 14.00             Session: “Targeted Drug Delivery and Experimental Therapies

                                               Chairpersons – Wiesław Szeja & Anna Kasprzycka

Grzegorz Grynkiewicz (Pharmaceutical Research Institute, Warszawa): Sustainable chemistry for a circular economy [online].

Andrzej Gamian/Beata Orzechowska (Institute of Immunology and Experimental Therapy, Wrocław): Viral vaccines - new challenges [online].

Tomasz Sarnowski (Institute of Biochemistry and Biophysics, Warszawa): M13 bacteriophage and anti-SARS-CoV-2 VHH as a potential therapy against COVID-19 [online].

Ilona Wandzik (Silesian University of Technology, Gliwice): Micro- and nanosized hydrogels for biomedical applications [online].

Katarzyna Jelonek (Centre of Polymer and Carbon Materials, Zabrze): Biodegradable micelles for targeted delivery of anticancer drugs.

Wiesław Szeja (Silesian University of Technology, Gliwice): Glut-targeting improves the properties of drug glycoconjugates in relation to neoplastic cells.

14.00 – 15.30             Virtual Poster Session (part 2)/coffee

Short presentations of selected posters (5 minutes allocated to each presentation)

Poster Session 2

  1. Marta Kasprzyk Functional dissection of IGH enhancers and enhancer RNAs in B-cell lymphomas
  2. Paulina Marona The role of MCPIP1 protein in tumor initiation and stemness of normal epithelial cells
  3. Marta Podralska Identification of irradiation-induced ATM-dependent lncRNAs
  4. Damian Sojka p53-depletion enhances colon cancer cells' resistance to manumycin A
  5. Magdalena Surman Ectosomal transfer of αvβ3 and αvβ5 integrins from melanoma cells to recipient vascular endothelial cells promotes their migration
  6. Agnieszka Gogler-Pigłowska Deficiency of the HSPA2 gene promotes a more differentiated phenotype of human epidermal keratinocytes and induces alterations in the organization of the three-dimensional reconstructed epidermis
  7. Paweł Piłat Identification of partners interacting with N4BP1 protein and determination of its cellular functions and localization
  8. Joanna Syrkis Immunohistochemically detected LOX expression is higher in metastases than in primary tumors in ovarian cancer
  9. Wiktoria Płonka The impact of DGCR8 inhibition on microRNA biogenesis in B-cell lymphoma
  10. Agnieszka Będzińska The dual role of p53 in regulation of interferon signaling pathways
  11. Patryk Janus The role of HSF1 in the regulation of the transcriptional response to estrogen at the level of chromatin organization
  12. Sybilla Matuszczak Influence of the tumor microenvironment on the effectiveness of radiotherapy of head and neck squamous cell carcinomas in vitro
  13. Łukasz Skoczylas HPV-positive head and neck squamous cell carcinoma cells release exosomes carrying HPV peptides
  14. Weronika Szukała Mcpip1 in skin tumorigenesis
  15. Weronika Bagrowska Modelling the cytoplasmic domain of the Toll-like receptor and initial studies of structure's dynamics

15.30 – 15.45              Presentation of awarded posters and closing remarks

15.45 –                       Lunch

 

Conference venue:

Maria Skłodowska-Curie National Research Institute of Oncology, Gliwice Branch,

Wybrzeże Armii Krajowej 15, 44-102 Gliwice, Jeremi Święcki Lecture Room.

Given the ongoing and expected effects of COVID-19, we plan to hold a hybrid type meeting with a limited number of participants in person and with online access to a wider audience.