Friday, November 23

10.00-10.10         Opening Address:
                Joanna Rzeszowska-Wolny (Head of Department.of Experimental & Clininical Radiobiology, Center of Onkology, Gliwice)
                Zygmunt Frankiewicz (Mayor of Gliwice City)

10.10-12.10
Session I:        Chromatin structure and function

Ronald Hancock (University Laval, Quebec):
Molecular crowding and assembly of nuclear compartments.

Nocolais Sjakste (Ryga, Latvia):
Proteasome role in pathology, first studies on proteasome gene polymorphism.

Jan Filipski (Universites Paris VII):
Localization of the hot spots of recombination in segments of human DNA cloned in YACs.

T. Kubicarowa, E. Sykorowa, J. Fajkus (Instuitute of Biophysics, Brno):
Chromatin structure of plant telomeres and subtelomeres.

12.10-12.30         Coffe break

12.30-13.30
Session II:         Cellular stress and death

Irena Szumiel (Institute of Nuclear Chemistry and Technology, Warsaw):
The celluar response to DNA damage; the importance of being p35 positive.

Maciej Żylicz (University of Gdańsk):
Role of the heat shock proteins in cell transformation.

13.30-14.30         Lunch

14.30-16.15
Ewa Nino (INSERM, Paris):
Oxidized low density lipoproteins in the process of atherosclerosis.

I. Gadek-Wesierski (Institute of Cancer Research, Vienna):
Inducion of apoptosis in human cervix carcinoma cells during therapy by cisplatin.

Andrzej Pawlak (Institute of Human Genetics PAN, Poznań):
Mutations of aryl hydrocarbon responsive elements (AHRE) determine the tissue specific genotoxic consequences of PAH exposure.

Tatiana Kałuża (Applied Biosystems):
Real - Time PCR.

16.15-16.30         Coffe break

16.30-18.45
Session III:         Mathematical modelling of biological processes

Marek Kimmel (Rice University, Houston):
SNP haplotypes and cancer.

Bogdan Lesyng (University of Warsaw):
Modelling of biomolecular systems and processes using microscopic and mezoscopic approaches.

M. Lachowicz (University of Warsaw):
Mathematical modelling of non-local phenomena in tumor development.

Krzysztof Fujarewicz (Silesian University of Technology, Gliwice):
Improved classification of microarray gene expression data using support vector machine.

C. Labuda (Symbios):
New trends in molecular diagnostics.

20.00         Dinner and get together party

Saturday, November 24

10.00-11.30
Session IV:         DNA damage and repair

Jacques Nino (Ecole Normale, Paris):
Mutation strategies.

Ryszard Oliński (Medical Academy, Bydgoszcz):
Oxidative stress and cancer development.

Krzysztof Szyfter ( Institute of Human Genetics PAN, Poznań):
A link between chromosome instability, DNA damage and repair capacity and cancer risk factor.

11.30-11.45         Coffe break

11.45-12.50
Piotr Widłak (Institute of Oncology, Gliwice):
Nucleases engaged in cell death.

Marek Rusin, Dorota Butkiewicz, Małgorzata Pawlas ( Institute of Oncology, Gliwice):
DNA damage recognition protein XPA - regulation of its expression and function.

Dorota Dziadkowiec (Wrocław University):
DNA repair and mating type switching in Schizosaccharomyces pombe.

13.15-13.25         Discussion and closing remarks

13.30-14.10         Lunch

2) E. Gubała, D. Handkiewicz-Junak, M. Zeman, E. Chmielik, M. Wiench, B. Jarząb
Nuclear Medicine and Endocrine Oncology Department, Oncology Center - Maria Skłodowska-Curie Memorial Institute, Gliwice, Poland
Thyroglobulin mRNA in fine needle aspirates of neck lymph nodes in patiens with differentiated thyroid cancer.

3) P. Kowalczyk, J. M. Cieśla, M. A. Grąziewicz, J. T. Kuśmierek, B. Tudek
Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland
DNA damage in p53 gene by chloroacetaldehyde and trans-4-hydroxy-2-noneal.

4) J. Mankiewicz¹, M. Tarczyńska², O. Palyvoda^3,4, Z. Walter¹, M. Wojtysiak- Staniaszczyk¹, M. Zalewski^2
1 Department of Molecular Genetics, University of Łódź, Poland,
² Department of Applied Ecology, University of Łódź, Poland,
³ Department of Experimental and Clinical Radiobiology, Oncology Center - Maria Skłodowska-Curie Memorial Institute, Gliwice, Poland,
⁴Department of Cell Signalling, Institute of Cell Biology, National Academy of Sciences of Ukraine, Lviv, Ukraine
Genotoxicity of microcystic cynobacterial extracts determined by SOS chromotest and comet assay.

5) Ł. Matulewicz^1,2, O. Palyvoda^1,3, W. Przybyszewski¹, B. Lubecka¹, M. Wideł^1
1Department of Experimental and Clinical Radiobiology, Oncology Center - Maria Skłodowska-Curie Memorial Institute, Gliwice, Poland
²Department of Medical Physics, Silesian University, Katowice, Poland,
³Department of Cell Signaling Institute of Cell Biology National Academy of Sciences of Ukraine, Lviv, Ukraine
Dose rate effect on tumour cells measured by comet assay.

6) D. Mielżyńska¹, K. Szyfter², E. Siwińska, L. Kapka, R. Jaskuła-Sztul², A. Rokicka³, E. Gutmajster³, D. Dziekanowska^3
1Laboratory of Environmental Mutagenesis, Institute of Occupational Medicine and Environomental Health, Sosnowiec, Poland,
²Laboratory of Mutagenesis, Institute of Human Genetics, Polish Academy of Sciences, Poznań, Poland,
³Department of General and Molecular Biology and Genetics, Silesian Medical Academy, Katowice, Poland
The exposure to PAH of children living in Silesia province in relation to the polymorphism of detoxification genes.

7) O. Palyvoda^1,2, J. Polańska³, J. Rzeszowska-Wolny^2
1Department of Experimental and Clinical Radiobiology, Oncology Center - Maria Skłodowska-Curie Memorial Institute, Gliwice, Poland,
²Department of Cell Signalling Mechanisms, Institute of Cell Biology, National Academy of Sciences of Ukraine, Lviv, Ukraine,
³Silesian University of Technology, Institute of Automatic Control, Gliwice, Poland
Radiation - Induced DNA damage and its removal in lymphocytes of patients with head and neck cancer and healthy donors studied with comet assay.

8) E. Strauss¹, E. Florek², A. L. Pawlak^1
1Institute of Human Genetics, Polish Academy of Sciences, Poznań, Poland,
²Medical University, Poznań, Poland
Effects of cigarette smoke on the sex ratio in progeny of c57bl congenic mice differing in alleles of ahr gene.

9) P. Konrad¹, R. Zielke¹, A. Czyż^2
1Department of Molecular Biology, University od Gdańsk, Poland,
²Labolatory of Molecular Biology, Institute of Biochemistry and Biophysics, Polish Academy of Science, Gdańsk, Poland
Influence of physical and chemical mutagens on luminescence level in bacteria.

10) K. Ułanowska¹, J. Piosik², A. Czyż³, J. Kapuściński², G. Węgrzyn^1
1Department of Molecular Biology, University of Gdańsk, Poland,
²Intercollegiate Faculty of Biotechnology University of Gdańsk and Medical University of Gdańsk, Poland,
³Laboratory of Molecular Biology, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Gdańsk, Poland
Caffeine and pentoxyfilline inhibited action of some chemical mutagens.

11) M. Głowala¹, V. Piddubnyak², A. Fiszer-Kierzkowska¹, A. Mazurek¹, Z. Krawczyk^1
1Department of Tumour Biology, Oncology Center - Maria Skłodowska-Curie Memorial Institute, Gliwice, Poland,
²Department of Oncology, Lviv State Medical University, Lviv, Ukraine,
Cytoprotective and anti-apoptoptic effect of hsp70i overexpression in V79 cell line.

12) A. Fiszer-Kierzkowska, A. Wysocka, B. Sarecka, K. Lisowska, Z. Krawczyk
Department of Tumour Biology, Oncology Center - Maria Skłodowska-Curie Memorial Institute, Gliwice, Poland
Functional analysis of sequences upstream of the rat hsp70.1 stress gene.

13) A.A. Shevalye, S.N. Kirko, V.S. Slyszenkov, A.V. Liopo
Institute of Biochemistry National Academy of Sciences of Belarus, Grodno, Belarus
Features of acetaldehyde influence on membranes of isolated nerve endings.

14) A. Wysocka¹, N. Vydra², A. Fiszer-Kierzkowska¹, K. Lisowska¹, Z. Krawczyk^1
1Department of Tumour Biology, Oncology Center - Maria Skłodowska-Curie Memorial Institute, Gliwice, Poland
²Institute of Biochemistry, National Academy of Sciences of Belarus, Grodno, Belarus
Effect of lipofectine on the hsp70 gene expression in B16 cells.

15) W. Widłak¹, D. Ścieglińska¹, N. Vydra², Z. Krawczyk¹
Department of Tumor Biology, Centre of Oncology, Maria Skłodowska - Curie Memorial Institute, Gliwice, Poland
Comparision of effectivenes and reliability of the in vivo electroporation of testis, in vitro transfection of somatic cells and transgenic mice as models to study regulation of spermatogenesis - specific hst70 gene.

16) M. Wiench, J. Włoch, M. Oczko, E. Gubała, B. Jarząb
Department of Nuclear Medicine and Endocrine Oncology, Oncology Center - Maria Skłodowska-Curie Memorial Institute, Gliwice, Poland
Papillary thyroid carcinoma: RET/PTC rearrangement as age-related lesion.

17) H. Zientek¹, M. Siemińska¹, A. Jasińska², M. Rusin¹, J. Michalska¹, P. Kozłowski², A. Sikorska², E. Kwiatkowska², E. Kalinowska¹, J. Pamuła¹, K. Sobczak², J. Rogozińska-Szczepka¹, B. Utracka-Hutka¹, M. Kazimierczak-Maciejewska¹, E. Chmielik¹, W. Krzyżosiak², E. Grzybowska^1
1Oncology Center - Maria Skłodowska-Curie Memorial Institute, Department of Tumor Biology, Gliwice, Poland,
²Institute of Bioorganic Chemistry, Polish Academy of Sciences, Laboratory of Cancer Genetics, Poznań, Poland
Frequency of recurrent mutations in BRCA1, BRCA2 and TP53 mutations in families with breast and ovarian cancer from Upper Silesia in Poland.

18) A. Kowalczyk, K. Guzik, K. Slezak, J. Dziedzic, H. Rokita
Jagiellonian University, Institute of Molecular Biology, Kraków, Poland
Heat shock protein expression and heat shock factor 1 subcelluar localization in vaccina virus infected human blood adherent monocytes.