Conference takes place in
Center of Oncology - M. Skłodowska-Curie Memorial Institute,
Branch in Gliwice,
Wybrzeże Armii Krajowej 15,
44-100 Gliwice

Friday, November 19^th

9.15-9.30         Opening of the Conference
                Opening address: prof. Joanna Rzeszowska, President of the Organising Committee
                Welcome address: Representative of Major of Gliwice City

9.30-11.45    Session I
MATEMATICAL MODELS IN GENOMICS AND CANCER BIOLOGY
Session supported by Apple IMC Poland SAD

Michał Dąbrowski (Nencki Institute, Warsaw):
Identification of potential cis-regulatory features associated with a mode of gene expression common to neuronal differentiation and hippocampal development.(30')

Krzysztof Fujarewicz (Silesian University of Technology, Gliwice):
Identification of models of cell signaling pathways. (25')

Piotr Formanowicz (Institute of Bioorganic Chemistry, Poznań):
Isothermic sequencing by hybridisation.(25')

Krzysztof Simek (Silesian University of Technology, Gliwice):
SVD as a tool for pattern discovery in gene expression data.(25')

Bogdan Smołka (Silesian University of Technology, Gliwice):
Fast denoising of cDNA microarray images.(25')


11.45-12.15 Coffee break + Poster viewing


12.15-14.00 Session II
STRUCTURE AND FUNCTION OF THE GENOME

Sergey Razin (Institute of Gene Biology, Moscow):
The spatial organization of DNA in eukaryotic cell nuclei plays an important role in determining positions of recombination hot-spots.(30')

Jan Filipski (Institut Jaques Monod, Paris):
Epigenetic regulation of transcription and the origin of isochors. (25')

Piotr Widłak (Center of Oncology, Gliwice):
The other face of histone H1. (25')

Introductory lecture:
Vasyl F. Chekhun (Institute of Experimental Pathology, Oncology and Radiobiology, Kiev)
New trends in experimental oncology in Ukraine. (25')

14.00-15.00 Lunch

15.00-18.30 Session III
DNA REPAIR MECHANISMS AND THEIR ROLE IN CARCINOGENESIS

Antonina Cebulska-Wasilewska (Institute of Nuclear Physics, Kraków):
Response to challenging dose of x-rays as biomarker of susceptibility in molecular epidemiology.(25')

Wolfgang Goedecke (University of Essen, Germany):
The fate of DNA double-strand breaks: aspects of mitotic and meiotic cells.(25')

Andrzej Wójcik (Institute of Nuclear Chemistry and Technology, Warsaw):
Do interindividual differences in lymphocyte chromosome radiosensitivity exist? (25')

Ulla Kasten-Pisula (Eppendorf University, Hamburg):
Molecular mechanisms of the individual radiosensitivity: impact on DNA repair.(25')

Coffee break + Poster viewing (30')

Paweł Jałoszyński (Institute of Human Genetics, Poznan):
Fidelity or survival? How unrepaired DNA is replicated when polymerases encounter problems.(25')

Barbara Tudek (Institute of Biochemistry and Biophysics, Warsaw):
Processing of lipid peroxidation-derived DNA adducts by repair enzymes and DNA polymerases.(25')

Miroslav Chovanec (Cancer Research Institute, Bratislava)
Repair of DNA double-strand breaks of different origin in Saccharomyces cerevisiae.(25')


20.00 - Social Party


Saturday, November 20^th

9.00-11.15 Session IV
CELLULAR STRESS, SIGNALING PATHWAYS AND CANCER
Session supported by Committee for Human Genetics and Molecular Pathology, PAS

Maciej Żylicz (International Institute Molecular and Cell Biology, Warsaw):
Hsp70 and MDM2 are important for the transcriptional activity of wild type p53.(30')

Joanna Rzeszowska (Center of Oncology, Gliwice):
Gene expression profiles and cellular stress.(25')

Svetlana Sidorenko (Institute of Experimental Pathology, Oncology and Radiobiology, Kiev):
CD150-mediated signaling.(25')

Lyudmila Sidorik (Institute of Molecular Biology and Genetics, Kiev, Ukraine):
The role of molecular chaperons in cancer.(25')

Jekaterina Erenpreisa (Latvian University, Riga):
Expression of meiotic genes and phenotype by irradiated tumour cells. (25')


11.15-11.45 Coffee break Poster viewing

11.45-13.00 Session V
NEW CONCEPTS AND METHODS

Lise L. Hansen (Aarhus University Hospital, Aarhus)
PCR amplification of highly GC-rich templates. An efficient tool in the search for new prognostic markers in cancer.(30')

Janusz M. Bujnicki (International Institute of Molecular and Cellular Biology, Warsaw)
Protein structure prediction by consensus fold recognition and assembly of fragments. (30')

Gabriel Wcisło (Military Medical Institute, Oncology Department, Warsaw):
From molecular studies to clinical practice. An EGFR (epidermal growth factor receptor) story.(15')


13.00-14.00 Lunch
14.00-16.15 Session VI
FUNCTIONAL GENOMICS IN MEDICINE
Session sponsored by State Committee for Scientific Research (Grant PBZ-KBN-040/PO4/2001)

Barbara Jarząb (Center of Oncology, Gliwice):
Genomic approach to thyroid cancer (25')

Małgorzata Wiench (Center of Oncology, Gliwice):
RET protooncogene and gene expression profile of thyroid cancer. (25')

Joanna Polańska (Silesian University of Technology, Gliwice):
Applications of mixture models to gene expression profiles.(25')

Katarzyna Lisowska (Center of Oncology, Gliwice):
Gene expression profiling in hereditary breast cancer; preliminary results.(25')

Michał Jarząb (Center of Oncology, Gliwice):
From microarray data to the biological relevance (25')


16.15-16.30 Closing Ceremony
Coffee/Discussions